BMS 193885

CAS No. 679839-66-8

BMS 193885 ( BMS193885 )

Catalog No. M27607 CAS No. 679839-66-8

BMS-193885 is an effective and selective neuropeptide Y1 receptor antagonist (IC50: 5.9nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 178 Get Quote
5MG 282 Get Quote
10MG 358 Get Quote
25MG 718 Get Quote
50MG 1228 Get Quote
100MG 1618 Get Quote
200MG 2428 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    BMS 193885
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-193885 is an effective and selective neuropeptide Y1 receptor antagonist (IC50: 5.9nM).
  • Description
    BMS-193885 is an effective and selective neuropeptide Y1 receptor antagonist (IC50: 5.9nM).(In Vitro):BMS 193885 increases the Kd of [(125)I]PeptideYY from 0.35 nM to 0.65 nM without changing the Bmax (0.16 pmol/mg of protein) in SK-N-MC cells that endogenously express the neuropeptide Y(1) receptor. BMS 193885 is a full antagonist with an apparent Kb of 4.5 nM measured by reversal of forskolin-stimulated inhibition of cAMP production by neuropeptide Y.(In Vivo):BMS 193885 (10 mg/kg; i.p.) reduces one-hour neuropeptide Y-induced food intake in satiated rats, as well as spontaneous overnight food consumption. Chronic administration of BMS 193885 (10 mg/kg) i.p. for 44 days significantly reduces food intake and the rate of body weight gain compared to vehicle treated control without developing tolerance or affecting water intake.
  • Synonyms
    BMS193885
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    679839-66-8
  • Formula Weight
    680.8
  • Molecular Formula
    C36H48N4O9
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [H][C@@](C)(O)C(O)=O.COC(=O)C1=C(C)NC(C)=C(C1c1cccc(N\C(O)=N\CCCN2CCC(CC2)c2cccc(OC)c2)c1)C(=O)OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nele Pien, et al. Proteomics as a tool to gain next level insights into photo-crosslinkable biopolymer modifications. Bioactive Materials, Volume 17, 2022, Pages 204-220.
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