BMS 193885
CAS No. 679839-66-8
BMS 193885 ( BMS193885 )
Catalog No. M27607 CAS No. 679839-66-8
BMS-193885 is an effective and selective neuropeptide Y1 receptor antagonist (IC50: 5.9nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 178 | Get Quote |
|
5MG | 282 | Get Quote |
|
10MG | 358 | Get Quote |
|
25MG | 718 | Get Quote |
|
50MG | 1228 | Get Quote |
|
100MG | 1618 | Get Quote |
|
200MG | 2428 | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBMS 193885
-
NoteResearch use only, not for human use.
-
Brief DescriptionBMS-193885 is an effective and selective neuropeptide Y1 receptor antagonist (IC50: 5.9nM).
-
DescriptionBMS-193885 is an effective and selective neuropeptide Y1 receptor antagonist (IC50: 5.9nM).(In Vitro):BMS 193885 increases the Kd of [(125)I]PeptideYY from 0.35 nM to 0.65 nM without changing the Bmax (0.16 pmol/mg of protein) in SK-N-MC cells that endogenously express the neuropeptide Y(1) receptor. BMS 193885 is a full antagonist with an apparent Kb of 4.5 nM measured by reversal of forskolin-stimulated inhibition of cAMP production by neuropeptide Y.(In Vivo):BMS 193885 (10 mg/kg; i.p.) reduces one-hour neuropeptide Y-induced food intake in satiated rats, as well as spontaneous overnight food consumption. Chronic administration of BMS 193885 (10 mg/kg) i.p. for 44 days significantly reduces food intake and the rate of body weight gain compared to vehicle treated control without developing tolerance or affecting water intake.
-
SynonymsBMS193885
-
PathwayOthers
-
TargetOther Targets
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number679839-66-8
-
Formula Weight680.8
-
Molecular FormulaC36H48N4O9
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES[H][C@@](C)(O)C(O)=O.COC(=O)C1=C(C)NC(C)=C(C1c1cccc(N\C(O)=N\CCCN2CCC(CC2)c2cccc(OC)c2)c1)C(=O)OC
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Nele Pien, et al. Proteomics as a tool to gain next level insights into photo-crosslinkable biopolymer modifications. Bioactive Materials, Volume 17, 2022, Pages 204-220.
molnova catalog
related products
-
Direct Red 80
Direct Red 80 is a tetra azo dye. It can be used to detect amyloid and can magnify the usual birefringence of collagen fibers in tissue sections.
-
Cefodizime Sodium
Cefodizime Sodium is a third generation cephalosporin antibiotic has broad-spectrum activity.
-
β-Amyloid (1-42), ra...
β-Amyloid (1-42), rat TFA is a 42-aa peptide, shows the effects of cytotoxicity on acute hippocampal slices, and has been used in studies of alzheimer's disease.