BMS 193885

Research use only, not for human use.

BMS-193885 is an effective and selective neuropeptide Y1 receptor antagonist (IC50: 5.9nM).

BMS-193885 is an effective and selective neuropeptide Y1 receptor antagonist (IC50: 5.9nM).(In Vitro):BMS 193885 increases the Kd of [(125)I]PeptideYY from 0.35 nM to 0.65 nM without changing the Bmax (0.16 pmol/mg of protein) in SK-N-MC cells that endogenously express the neuropeptide Y(1) receptor. BMS 193885 is a full antagonist with an apparent Kb of 4.5 nM measured by reversal of forskolin-stimulated inhibition of cAMP production by neuropeptide Y.(In Vivo):BMS 193885 (10 mg/kg; i.p.) reduces one-hour neuropeptide Y-induced food intake in satiated rats, as well as spontaneous overnight food consumption. Chronic administration of BMS 193885 (10 mg/kg) i.p. for 44 days significantly reduces food intake and the rate of body weight gain compared to vehicle treated control without developing tolerance or affecting water intake.

——

——

BMS193885

Others

Other Targets

——

——

——

679839-66-8

680.799

C36H48N4O9

>98% (HPLC)

——

[H][C@@](C)(O)C(O)=O.COC(=O)C1=C(C)NC(C)=C(C1c1cccc(N\C(O)=N\CCCN2CCC(CC2)c2cccc(OC)c2)c1)C(=O)OC

——

(-20℃)

With Ice Pack

≥ 2 years